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Article

The role of TP53 gain-of-function mutation in multifocal glioblastoma.

Journal of neuro-oncology - 1 Mar 2020

Olafson Lauren R, Gunawardena Manuri, Nixdorf Sheri, McDonald Kerrie L, Rapkins Robert W

Abstract excerpt

PURPOSE: The phenotypic and genotypic landscapes in multifocal glioblastoma (MF GBM) cases can vary greatly among lesions. In a MF GBM patient, the rapid development of a secondary lesion was investigated to determine if a unique genetic signature could account for the apparent increased malignancy of this lesion. METHODS: The primary (G52) and secondary (G53) tumours were resected to develop patient derived...

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Source

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Identifiers

PMID: 32002804
DOI: 10.1007/s11060-019-03318-5
PMCID: PMC7075848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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