Article

p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis

2021-06-11

Abstract excerpt

The tumor suppressor TP53 is the most frequently mutated gene in cancer. Most TP53 mutations are missense mutations in the DNA-binding domain, which in addition to loss of canonical p53 activity, frequently confer gain-of-function (GOF) aberrant transcriptional activity through mutant p53 localization to non-canonical genes. GOF phenotypes differ by mutation and cell identity and are reported to include increased...

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Literature Corpus work: 38158631-050e-5aed-9cb1-82b710588435
DOI: 10.1101/2021.06.11.448124

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