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The p53 Pathway in Glioblastoma

1 Sept 2018

Abstract excerpt

The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by orchestrating a wide variety of cellular responses, including damaged cell apoptosis, maintenance of genomic stability, inhibition of angiogenesis, and regulation of cell metabolism and tumor microenvironment. TP53 is one of the most commonly deregulated genes in cancer. The p53-ARF-MDM2 pathway is deregulated in 84% of...

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PMID: 30200436
DOI: 10.3390/cancers10090297

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