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Article

Biallelic TP53 gain of function mutations in rapidly progressing solid tumors.

Cancer genetics - 1 Apr 2018

Sande Christopher M, Chang Brian, Monga Varun, Bossler Aaron D, Ma Deqin

Abstract excerpt

Recent studies are discovering TP53 mutations with gain of function (GOF) properties that promote tumorigenesis via a variety of mechanisms. To our knowledge, all reported compound mutations are allelic. We identified two patients with biallelic GOF TP53 mutations in their tumors and a third with allelic compound variants. The correlation with p53 expression was also examined. Genomic DNA was extracted from...

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Identifiers

PMID: 29666004
DOI: 10.1016/j.cancergen.2018.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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