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Article

Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.

Brain pathology (Zurich, Switzerland) - 1 Jul 1996

Watanabe K, Tachibana O, Sata K, Yonekawa Y, Kleihues P, Ohgaki H

Abstract excerpt

Glioblastoma multiforme, the most malignant human brain tumor, may develop de novo (primary glioblastoma) or through progression from low-grade or anaplastic astrocytoma (secondary glioblastoma). We present further evidence that primary and secondary glioblastomas constitute distinct disease entities which develop through the acquisition of different genetic alterations. We analyzed p53 mutations, p53 protein...

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Share to DNA, Neoplasm
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, p53

Share to Immunohistochemistry

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Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 8864278
DOI: 10.1111/j.1750-3639.1996.tb00848.x

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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