Article
Systemic metastasis in glioblastoma may represent the emergence of neoplastic subclones.
Journal of neuropathology and experimental neurology - 1 Dec 2000
Park C C, Hartmann C, Folkerth R, Loeffler J S, Wen P Y, Fine H A, Black P M, Shafman T, Louis D N
Abstract excerpt
Glioblastomas only rarely metastasize to sites outside the central nervous system, for reasons that are poorly understood. We report the clinicopathological and molecular genetic findings in 6 patients with metastatic glioblastoma. Four patients were under the age of 32 and all but 1 patient died within 2 yr of diagnosis. The number of metastases ranged from 1 to 3. At the time of death, 3 patients had apparent...
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