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Article

Isoniazid and Rifampin-Resistance Mutations Associated With Resistance to Second-Line Drugs and With Sputum Culture Conversion.

The Journal of infectious diseases - 11 Jun 2020

Click Eleanor S, Kurbatova Ekaterina V, Alexander Heather, Dalton Tracy L, Chen Michael P, Posey James E, Ershova Julia, Cegielski J Peter

Abstract excerpt

BACKGROUND: Mutations in the genes inhA, katG, and rpoB confer resistance to anti-tuberculosis (TB) drugs isoniazid and rifampin. We questioned whether specific mutations in these genes were associated with different clinical and microbiological characteristics. METHODS: In a multicountry prospective cohort study of multidrug-resistant TB, we identified inhA, katG, and rpoB mutations in sputum isolates using the...

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Identifiers

PMID: 32002554
DOI: 10.1093/infdis/jiaa042
PMCID: PMC7289556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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