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Pattern and prevalence of rifampicin and isoniazid-resistant tuberculosis using genotype MTBDRplus assay in Ethiopia.

Microbiology spectrum - 7 Apr 2026

Getahun Muluwork, Ameni Gobena, Mollalign Hilina, Diriba Getu, Beyene Dereje

Abstract excerpt

Resistance-conferring mutations in Mycobacterium tuberculosis (Mtb) are primary drivers of therapeutic challenges. However, comprehensive resistance mutation profiles are lacking in low- and middle-income countries. This study assesses the patterns and prevalence of isoniazid (INH) or multidrug/rifampicin-resistant (MDR/RR) tuberculosis (TB) mutations. We used stored Mtb isolates obtained from smear-positive TB...

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Identifiers

PMID: 41718507
DOI: 10.1128/spectrum.01454-25
PMCID: PMC13055254

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LPA

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