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Article

Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women.

Experimental hematology - 1 Sept 2016

Wiedmeier Julia Erin, Kato Catherine, Zhang Zhenzhen, Lee Hyunjung, Dunlap Jennifer, Nutt Eric, Rattray Rogan, McKay Sarah, Eide Christopher, Press Richard, Mori Motomi, Druker Brian, Dao Kim-Hien

Abstract excerpt

Recent large cohort studies revealed that healthy older individuals harbor somatic mutations that increase their risk for hematologic malignancy and all-cause cardiovascular deaths. The majority of these mutations are in chromatin and epigenetic regulatory genes (CERGs). CERGs play a key role in regulation of DNA methylation (DNMT3A and TET2) and histone function (ASXL1) and in clonal proliferation of...

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Share to Clonal Evolution
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Epigenesis, Genetic

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Receptors, Androgen

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27235757
DOI: 10.1016/j.exphem.2016.05.009
PMCID: PMC4993458

Genes

ASXL1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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