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Article

Calciprotein particles regulate fibroblast growth factor-23 expression in osteoblasts

8 Nov 2019

Abstract excerpt

Fibroblast growth factor-23 (FGF23) is a hormone indispensable for maintaining phosphate homeostasis. In response to phosphate intake, FGF23 is secreted from osteocytes/osteoblasts and acts on the kidney to increase urinary phosphate excretion. However, the mechanism by which these cells sense phosphate intake remains elusive. Calciprotein particles are nanoparticles of calcium-phosphate precipitates bound to...

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PMID: 32001068
DOI: 10.1016/j.kint.2019.10.019

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