Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGF23 in skeletal modeling and remodeling.

Current osteoporosis reports - 1 Jun 2011

Lu Yongbo, Feng Jian Q

Abstract excerpt

Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance. Excessive serum FGF23 due to hereditary disorders such as hypophosphatemic rickets leads to phosphate wasting and impaired bone mineralization. In contrast, deficiencies in FGF23 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Fibroblast Growth Factor-23
Share to Fibroblast Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypophosphatemia

Share to Osteoblasts

Share to Rickets

Share to Vitamin D

Source

Open in PubMed Open full text

Identifiers

PMID: 21404002
DOI: 10.1007/s11914-011-0053-4
PMCID: PMC3268056

Genes

FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGF23 in skeletal modeling and remodeling.PMID 21404002Read ↗

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.Semantic proximity Read ↗

FGF23–GH Crosstalk in Phosphate Allocation and Growth Plate BiologySemantic proximity Read ↗

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis.Semantic proximity Read ↗

Molecular pathology of the fibroblast growth factor family.Semantic proximity Read ↗

Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and DiseaseSemantic proximity Read ↗

[Regulation of fibroblast growth factor 23 in metabolic bone diseases].Semantic proximity Read ↗

Genetic evidence of serum phosphate-independent functions of FGF-23 on bone.Semantic proximity Read ↗

Latest findings in phosphate homeostasis.Semantic proximity Read ↗

Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemiaSemantic proximity Read ↗

FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.Semantic proximity Read ↗

Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia.Semantic proximity Read ↗

Congenital Hyperphosphatemic Conditions Caused by the Deficient Activity of FGF23.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.