Article

Coupling of Calcium Homeostasis and Formation and Secretion of Matrix Vesicles: Their Role in the Mechanism of Biomineralization

2025-04-02

Abstract excerpt

The human bone is a dynamic, highly vascularized tissue composed of 60-70% minerals, which include mainly calcium phosphate (CaP) in the form of hydroxyapatite (HA) crystals, 30% organic matrix composed of type I collagen fibers and less than 5% of water and lipids. The crystals are formed inside the matrix vesicles (MVs) and are then released in the organic collagen based fibrous matrix. Extracellular matrix (ECM...

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Literature Corpus work: c70ab2c4-b306-5dad-83a7-4e3080def6fb
DOI: 10.20944/preprints202504.0160.v1

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