Article
Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.
BMC cancer - 30 Jan 2020
Manoharan Vahinipriya, Karunanayake Eric Hamilton, Tennekoon Kamani Hemamala, De Silva Sumadee, Imthikab Ahamed Ilyas Ahamed, De Silva Kanishka, Angunawela Preethika, Vishwakula Sameera, Lunec John
Abstract excerpt
BACKGROUND: Breast cancer (BC) is known to be the most common malignancy in females whereas colorectal cancer (CRC) incidence also higher in both genders in Sri Lanka. TP53 is an important tumour suppressor gene and its somatic mutations are reported in approximately 27% of BC and 43% of CRC cases. Analysis of TP53 gene variants not only provides clues for the aetiology of the tumour formation, but also has an...
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