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Article

TP53 mutation status and consensus molecular subtypes of colorectal cancer in patients from Rwanda.

BMC cancer - 11 Oct 2024

Nzitakera Augustin, Uwamariya Delphine, Kato Hisami, Surwumwe Jean Bosco, Mbonigaba André, Ndoricyimpaye Ella Larissa, Uwamungu Schifra, Manirakiza Felix, Ndayisaba Marie Claire, Ntakirutimana Gervais, Seminega Benoit, Dusabejambo Vincent, Rutaganda Eric, Kamali Placide, Ngabonziza François, Ishikawa Rei, Watanabe Hirofumi, Rugwizangoga Belson, Baba Satoshi, Yamada Hidetaka, Yoshimura Katsuhiro, Sakai Yasuhiro, Sugimura Haruhiko, Shinmura Kazuya

Abstract excerpt

BACKGROUND: Mutations in the TP53 tumor suppressor gene are well-established drivers of colorectal cancer (CRC) development. However, data on the prevalence of TP53 variants and their association with consensus molecular subtype (CMS) classification in patients with CRC from Rwanda are currently lacking. This study addressed this knowledge gap by investigating TP53 mutation status concerning CMS classification in...

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PMID: 39394554
DOI: 10.1186/s12885-024-13009-8
PMCID: PMC11468329

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