Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus.

Rheumatology (Oxford, England) - 1 Sept 2020

Zaidi Faseeh, Narang Ravi K, Phipps-Green Amanda, Gamble Greg G, Tausche Anne-Katherin, So Alexander, Riches Philip, Andres Mariano, Perez-Ruiz Fernando, Doherty Michael, Janssen Matthijs, Joosten Leo A B, Jansen Tim L, Kurreeman Fina, Torres Rosa J, McCarthy Geraldine M, Miner Jeffrey N, Stamp Lisa K, Merriman Tony R, Dalbeth Nicola

Abstract excerpt

OBJECTIVE: The aim of this study was to examine whether serum urate-associated genetic variants are associated with early-onset gout. METHODS: Participants with gout in the Genetics of Gout in Aotearoa study with available genotyping were included (n = 1648). Early-onset gout was defined as the first presentation of gout <40 years of age. Single nucleotide polymorphisms (SNPs) for the 10 loci most strongly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Europe

Share to Genetic Predisposition to Disease

Share to Neoplasm Proteins

Share to Polymorphism, Single Nucleotide

Share to Uric Acid

Source

Identifiers

PMID: 31998961
DOI: 10.1093/rheumatology/kez685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus.PMID 31998961Read ↗

Common dysfunctional variants in ABCG2 are a major cause of early-onset goutSemantic proximity Read ↗

Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort.Semantic proximity Read ↗

Associations of the ALDH2 rs671 polymorphism and alcohol intake with early-onset gout in a Chinese male cohort.Semantic proximity Read ↗

A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk.Semantic proximity Read ↗

The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patientsSemantic proximity Read ↗

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.Semantic proximity Read ↗

Genetic advances in gout: potential applications in clinical practiceSemantic proximity Read ↗

Genetic variation in the ABCG2 gene is associated with gout risk in the Chinese Han population.Semantic proximity Read ↗

Synergistic effects of ABCG2 Q141K variant in combination with alcohol consumption and male sex on gout risk in a rare-event Taiwanese cohort.Semantic proximity Read ↗

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk FactorsSemantic proximity Read ↗

Functional non-synonymous variants of ABCG2 and gout risk.Semantic proximity Read ↗

The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.