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Article

The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients

20 Mar 2019

Abstract excerpt

BACKGROUND: ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dysfunctional ABCG2 variants, with rs2231142 (Q141K) being the most common. In this study, we analyzed the ABCG2 gene in a hyperuricemia and gout cohort focusing on...

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PMID: 30894219
DOI: 10.1186/s13075-019-1860-8

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