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Article

Functional non-synonymous variants of ABCG2 and gout risk.

Rheumatology (Oxford, England) - 1 Nov 2017

Stiburkova Blanka, Pavelcova Katerina, Zavada Jakub, Petru Lenka, Simek Pavel, Cepek Pavel, Pavlikova Marketa, Matsuo Hirotaka, Merriman Tony R, Pavelka Karel

Abstract excerpt

Objectives: Common dysfunctional variants of ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2), a high-capacity urate transporter gene, that result in decreased urate excretion are major causes of hyperuricemia and gout. In the present study, our objective was to determine the frequency and effect on gout of common and rare non-synonymous and other functional allelic variants in the ABCG2...

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Identifiers

PMID: 28968913
DOI: 10.1093/rheumatology/kex295

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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