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Article

Synergistic effects of ABCG2 Q141K variant in combination with alcohol consumption and male sex on gout risk in a rare-event Taiwanese cohort.

Scientific reports - 16 Feb 2026

Lai Zi-Lun, Hung Yuan-Hua, Su Yang-Di, Lin Chia-Yu, Li Yu-Hsiu, Chen Chia-Yu, Cho Der-Yang, Hsueh Po-Ren

Abstract excerpt

Gout is influenced by genetic and lifestyle factors, with ABCG2 variants (rs2231142 Q141K and rs72552713 Q126X) implicated in urate transport and susceptibility. Standard statistical models often yield biased estimates in rare-event cohorts. This cross-sectional study (N = 324, 15 gout cases) used Firth-corrected logistic regression to mitigate small-sample bias and address complete separation in ABCG2 genotyping...

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Source

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Identifiers

PMID: 41699042
DOI: 10.1038/s41598-026-39327-4
PMCID: PMC13000185

Genes

ABCG2

Variants

rs2231142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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