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Article

Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2025

Ji Aichang, Sui Yang, Xue Xiaomei, Ji Xiapeng, Shi Wenrui, Shi Yongyong, Terkeltaub Robert, Dalbeth Nicola, Takei Riku, Yan Fei, Sun Mingshu, Li Maichao, Lu Jie, Cui Lingling, Liu Zhen, Wang Can, Li Xinde, Han Lin, Fang Zhanjie, Sun Wenyan, Liang Yue, He Yuwei, Zheng Guangmin, Wang Xuefeng, Wang Jiayi, Zhang Hui, Pang Lei, Qi Han, Li Yushuang, Cheng Zan, Li Zhiqiang, Xiao Jingfa, Zeng Changqing, Merriman Tony R, Qu Hongzhu, Fang Xiangdong, Li Changgui

Abstract excerpt

OBJECTIVE: Mechanisms underlying the adolescent-onset and early-onset gout are unclear. This study aimed to discover variants associated with early-onset gout. METHODS: We conducted whole-genome sequencing in a discovery adolescent-onset gout cohort of 905 individuals (gout onset 12 to 19 years) to discover common and low-frequency single-nucleotide variants (SNVs) associated with gout. Candidate common SNVs were...

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Identifiers

PMID: 39118347
DOI: 10.1002/art.42969

Genes

RCOR1
ABCG2
FSTL5
SLC22A12

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