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Article

Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing.

Frontiers in immunology - 1 Jan 2019

Goodson-Gregg Frederick J, Rothbard Brian, Zhang Amy, Wright Paul W, Li Hongchuan, Walker-Sperling Victoria E, Carrington Mary, Anderson Stephen K

Abstract excerpt

A complex system regulating HLA-C expression in NK cells, driven by an NK-specific promoter that produces alternatively spliced variants of the 5'-UTR has been recently identified. Exon content of the NK-specific 5'-UTR varies strikingly across HLA-C alleles, with some exons being allele specific. In order to investigate the possibility that allelic variation in the 5'-UTR modulates HLA-C expression levels, cDNAs...

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Share to 5' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31998314
DOI: 10.3389/fimmu.2019.03034
PMCID: PMC6966967

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