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Article

Posttranscriptional Regulation of HLA-A Protein Expression by Alternative Polyadenylation Signals Involving the RNA-Binding Protein Syncrip.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2017

Kulkarni Smita, Ramsuran Veron, Rucevic Marijana, Singh Sukhvinder, Lied Alexandra, Kulkarni Viraj, O'hUigin Colm, Le Gall Sylvie, Carrington Mary

Abstract excerpt

Genomic variation in the untranslated region (UTR) has been shown to influence HLA class I expression level and associate with disease outcomes. Sequencing of the 3'UTR of common HLA-A alleles indicated the presence of two polyadenylation signals (PAS). The proximal PAS is conserved, whereas the distal PAS is disrupted within certain alleles by sequence variants. Using 3'RACE, we confirmed expression of two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29055006
DOI: 10.4049/jimmunol.1700697
PMCID: PMC5812486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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