Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.

doi:10.1038/nm.2366

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.

Nature medicine - 1 Jun 2011

Delahaye Nicolas F, Rusakiewicz Sylvie, Martins Isabelle, Ménard Cédric, Roux Stephan, Lyonnet Luc, Paul Pascale, Sarabi Matthieu, Chaput Nathalie, Semeraro Michaela, Minard-Colin Véronique, Poirier-Colame Vichnou, Chaba Kariman, Flament Caroline, Baud Véronique, Authier Hélène, Kerdine-Römer Saadia, Pallardy Marc, Cremer Isabelle, Peaudecerf Laetitia, Rocha Bénédita, Valteau-Couanet Dominique, Gutierrez Javier Celis, Nunès Jacques A, Commo Frédéric, Bonvalot Sylvie, Ibrahim Nicolas, Terrier Philippe, Opolon Paule, Bottino Cristina, Moretta Alessandro, Tavernier Jan, Rihet Pascal, Coindre Jean-Michel, Blay Jean-Yves, Isambert Nicolas, Emile Jean-François, Vivier Eric, Lecesne Axel, Kroemer Guido, Zitvogel Laurence

Abstract excerpt

The natural killer (NK) cell receptor NKp30 is involved in the recognition of tumor and dendritic cells (DCs). Here we describe the influence of three NKp30 splice variants on the prognosis of gastrointestinal sarcoma (GIST), a malignancy that expresses NKp30 ligands and that is treated with NK-s...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Stromal Tumors

Share to Interferon-gamma

Share to Interleukin-12

Share to Killer Cells, Natural

Share to Lysosomal-Associated Membrane Protein 1

Share to Protein Isoforms

Share to Proto-Oncogene Proteins c-kit

Source

Open in PubMed

Identifiers

PMID: 21552268
DOI: 10.1038/nm.2366

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21552268-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.PMID 21552268Read ↗

Genomic analysis reveals molecular characterization of CD30+ and CD30- extranodal natural killer/T-cell lymphomas (ENKTLs).Semantic proximity Read ↗

Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells.Semantic proximity Read ↗

NKp30 isoforms in patients with chronic hepatitis C virus infection.Semantic proximity Read ↗

The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.Semantic proximity Read ↗

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients.Semantic proximity Read ↗

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humansSemantic proximity Read ↗

KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells.Semantic proximity Read ↗

IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancerSemantic proximity Read ↗

First Trimester Pregnancy Loss and the Expression of Alternatively Spliced NKp30 Isoforms in Maternal Blood and Placental TissueSemantic proximity Read ↗

Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.Semantic proximity Read ↗

Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing.Semantic proximity Read ↗

CD30/CD30 Ligand (CD153) Interaction Regulates CD4+ T Cell-Mediated Graft-versus-Host DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.