A small-cell lung cancer genome with complex signatures of tobacco exposure.

doi:10.1038/nature08629

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Article

A small-cell lung cancer genome with complex signatures of tobacco exposure.

Nature - 14 Jan 2010

Pleasance Erin D, Stephens Philip J, O'Meara Sarah, McBride David J, Meynert Alison, Jones David, Lin Meng-Lay, Beare David, Lau King Wai, Greenman Chris, Varela Ignacio, Nik-Zainal Serena, Davies Helen R, Ordoñez Gonzalo R, Mudie Laura J, Latimer Calli, Edkins Sarah, Stebbings Lucy, Chen Lina, Jia Mingming, Leroy Catherine, Marshall John, Menzies Andrew, Butler Adam, Teague Jon W, Mangion Jonathon, Sun Yongming A, McLaughlin Stephen F, Peckham Heather E, Tsung Eric F, Costa Gina L, Lee Clarence C, Minna John D, Gazdar Adi, Birney Ewan, Rhodes Michael D, McKernan Kevin J, Stratton Michael R, Futreal P Andrew, Campbell Peter J

Abstract excerpt

Cancer is driven by mutation. Worldwide, tobacco smoking is the principal lifestyle exposure that causes cancer, exerting carcinogenicity through >60 chemicals that bind and mutate DNA. Using massively parallel sequencing technology, we sequenced a small-cell lung cancer cell line, NCI-H209, to e...

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Identifiers

PMID: 20016488
DOI: 10.1038/nature08629
PMCID: PMC2880489

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CHD7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20016488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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