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Article

Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma

27 Jan 2020

Abstract excerpt

Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at the EfnA5 locus and reinforces repression of selected target genes in a cellular context-dependent fashion. EfnA5 mediates...

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PMID: 31988455
DOI: 10.1038/s41388-020-1161-3

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