Article
Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.
Development (Cambridge, England) - 17 Feb 2020
Romagnoli Mathilde, Bresson Laura, Di-Cicco Amandine, Pérez-Lanzón María, Legoix Patricia, Baulande Sylvain, de la Grange Pierre, De Arcangelis Adèle, Georges-Labouesse Elisabeth, Sonnenberg Arnoud, Deugnier Marie-Ange, Glukhova Marina A, Faraldo Marisa M
Abstract excerpt
Integrin dimers α3/β1, α6/β1 and α6/β4 are the mammary epithelial cell receptors for laminins, which are major components of the mammary basement membrane. The roles of specific basement membrane components and their integrin receptors in the regulation of functional gland development have not been analyzed in detail. To investigate the functions of laminin-binding integrins, we obtained mutant mice with mammary...
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