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Article

Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.

Development (Cambridge, England) - 1 Sept 1999

De Arcangelis A, Mark M, Kreidberg J, Sorokin L, Georges-Labouesse E

Abstract excerpt

Integrins alpha6beta1 and alpha6beta4 are cell surface receptors for laminins. Integrin alpha6-null mice die at birth with severe skin blistering and defects in the cerebral cortex and in the retina. Integrin alpha3beta1 can associate with laminins and other ligands. Integrin alpha3-null mice als...

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Share to Basement Membrane
Share to Ectoderm
Share to Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fibroblast Growth Factors

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Share to Limb Deformities, Congenital

Source

Identifiers

PMID: 10433923
DOI: 10.1242/dev.126.17.3957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10433923-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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