Article
Laminin isoforms in development and disease.
Journal of molecular medicine (Berlin, Germany) - 1 Aug 2007
Schéele Susanne, Nyström Alexander, Durbeej Madeleine, Talts Jan F, Ekblom Marja, Ekblom Peter
Abstract excerpt
The members of the laminin family of heterotrimers are major constituents of all basement membranes, sheet-like extracellular structures, present in almost all organs. The laminins bind to cell surface receptors and thereby tightly connect the basement membrane to the adjacent cell layer. This provides for the specific basement membrane functions to stabilize cellular structures, to serve as effective physical...
Topics
- Animals
- Basement Membrane
- Dystroglycans
- Humans
- Integrins
- Laminin
- Models, Biological
- Muscular Diseases
- Mutation
- Protein Isoforms