Article
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.
Nature cell biology - 1 Jun 2008
Taddei Ilaria, Deugnier Marie-Ange, Faraldo Marisa M, Petit Valérie, Bouvard Daniel, Medina Daniel, Fässler Reinhard, Thiery Jean Paul, Glukhova Marina A
Abstract excerpt
The mammary gland epithelium comprises two major cell types: basal and luminal. Basal cells interact directly with the extracellular matrix (ECM) and express higher levels of the ECM receptors, integrins, than luminal cells. We show that deletion of beta1 integrin from basal cells abolishes the regenerative potential of the mammary epithelium and affects mammary gland development. The mutant epithelium was...
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