Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho.

American journal of physiology. Renal physiology - 1 Mar 2020

Li Peng, Shi Mingjun, Maique Jenny, Shaffer Joy, Yan Shirley, Moe Orson W, Hu Ming Chang

Abstract excerpt

Klotho- and beclin 1-driven autophagy extends life. We examined the role of beclin 1 in modifying acute kidney injury (AKI) and whether beclin 1 mediates Klotho's known renoprotective action in AKI. AKI was induced by ischemia-reperfusion injury in mice with different levels of autophagy activity by genetic manipulation: wild-type (WT) mice with normal beclin 1 expression and function, mice with normal beclin 1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Beclin-1
Share to Glucuronidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Peroxide

Share to Kidney Diseases

Share to Klotho Proteins

Share to Opossums

Share to Proto-Oncogene Proteins c-bcl-2

Share to Reperfusion Injury

Source

Open in PubMed Open full text

Identifiers

PMID: 31984794
DOI: 10.1152/ajprenal.00504.2019
PMCID: PMC7099499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho.PMID 31984794Read ↗

αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injurySemantic proximity Read ↗

Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice.Semantic proximity Read ↗

Amelioration of progressive renal injury by genetic manipulation of <i>Klotho</i> geneSemantic proximity Read ↗

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.Semantic proximity Read ↗

Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulationSemantic proximity Read ↗

Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 DiabetesSemantic proximity Read ↗

AKI after conditional and kidney-specific knockdown of stanniocalcin-1.Semantic proximity Read ↗

Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury.Semantic proximity Read ↗

Oxidative Stress Decreases Klotho Expression in a Mouse Kidney Cell LineSemantic proximity Read ↗

Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.Semantic proximity Read ↗

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice.Semantic proximity Read ↗

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.