Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice.

Clinical and experimental nephrology - 1 Oct 2016

Kadoya Hiroyuki, Satoh Minoru, Haruna Yoshisuke, Sasaki Tamaki, Kashihara Naoki

Abstract excerpt

BACKGROUND: Expression of klotho, the renoprotective anti-aging gene, is decreased in diabetic model kidneys. We hypothesized that klotho protein attenuates renal hypertrophy and glomerular injury in a mouse model of diabetic nephropathy. METHODS: Klotho transgenic (KLTG) mice were crossed with spontaneously diabetic Ins2Akita (AKITA) mice. Glomerular morphology, macrophage infiltration, urinary albumin excretion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 8-Hydroxy-2'-Deoxyguanosine
Share to Albuminuria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calpain

Share to Deoxyguanosine

Share to Glucuronidase

Share to Hypertrophy

Share to Kidney Glomerulus

Share to Klotho Proteins

Source

Identifiers

PMID: 26586006
DOI: 10.1007/s10157-015-1202-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice.PMID 26586006Read ↗

Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathySemantic proximity Read ↗

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.Semantic proximity Read ↗

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.Semantic proximity Read ↗

Klotho Deficiency Aggravated Diabetes-induced Podocyte injurySemantic proximity Read ↗

Amelioration of progressive renal injury by genetic manipulation of <i>Klotho</i> geneSemantic proximity Read ↗

Oxidative Stress Decreases Klotho Expression in a Mouse Kidney Cell LineSemantic proximity Read ↗

Toward a better understanding of Klotho.Semantic proximity Read ↗

αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injurySemantic proximity Read ↗

Molecular Basis of Klotho: From Gene to Function in AgingSemantic proximity Read ↗

Suppression of Aging in Mice by the Hormone KlothoSemantic proximity Read ↗

Klotho and aging.Semantic proximity Read ↗

Role of Klotho in the Development of Essential Hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.