Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes

4 Sept 2015

Abstract excerpt

Apoptosis is the major cause of death of insulin-producing β-cells in type 1 diabetes mellitus (T1DM). Klotho is a recently discovered antiaging gene. We found that the Klotho gene is expressed in pancreatic β-cells. Interestingly, halplodeficiency of Klotho (KL(+/-)) exacerbated streptozotocin (STZ)-induced diabetes (a model of T1DM), including hyperglycemia, glucose intolerance, diminished islet insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to Pancreatic function and diabetes
Share to Parathyroid Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26340932
DOI: 10.2337/db15-0066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 DiabetesPMID 26340932Read ↗

Suppression of Aging in Mice by the Hormone KlothoSemantic proximity Read ↗

The Antiaging Gene Klotho Regulates Proliferation and Differentiation of Adipose-Derived Stem CellsSemantic proximity Read ↗

Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice.Semantic proximity Read ↗

Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cellsSemantic proximity Read ↗

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549Semantic proximity Read ↗

Toward a better understanding of Klotho.Semantic proximity Read ↗

The Role of Alpha-Klotho as a Universal Tumor Suppressor.Semantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.Semantic proximity Read ↗

Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in agingSemantic proximity Read ↗

Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.