Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation

5 Dec 2023

Abstract excerpt

Background: Klotho deficiency is a common feature of premature aging and chronic kidney disease (CKD). As such, restoring Klotho expression could be a logic strategy for protecting against various nephropathies. In this study, we demonstrate that KP1, a Klotho-derived peptide, inhibits cellular senescence by restoring endogenous Klotho expression. Methods: The effects of KP1 on cellular senescence and Klotho...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to Parathyroid Disorders and Treatments
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38164143
DOI: 10.7150/thno.89105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulationPMID 38164143Read ↗

Klotho and the Treatment of Human MalignanciesSemantic proximity Read ↗

The Antisenescence Protein Klotho Is Necessary for FGF23-Induced PhosphaturiaSemantic proximity Read ↗

A study of the molecular mechanism of quercetin and dasatinib combination as senolytic in alleviating age‐related and kidney diseasesSemantic proximity Read ↗

Role of Klotho in the Development of Essential Hypertension.Semantic proximity Read ↗

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.Semantic proximity Read ↗

Cellular SenescenceSemantic proximity Read ↗

Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cellsSemantic proximity Read ↗

Klotho and aging.Semantic proximity Read ↗

Klotho: An Elephant in Aging ResearchSemantic proximity Read ↗

Molecular and Environmental Modulators of Aging: Interplay Between Inflammation, Epigenetics, and RNA StabilitySemantic proximity Read ↗

Inflammation and Premature Ageing in Chronic Kidney Disease.Semantic proximity Read ↗

Suppression of Aging in Mice by the Hormone KlothoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.