Article
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Nature - 1 Jun 2018
Fernández Álvaro F, Sebti Salwa, Wei Yongjie, Zou Zhongju, Shi Mingjun, McMillan Kathryn L, He Congcong, Ting Tabitha, Liu Yang, Chiang Wei-Chung, Marciano Denise K, Schiattarella Gabriele G, Bhagat Govind, Moe Orson W, Hu Ming Chang, Levine Beth
Abstract excerpt
Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established1,2. Here we report lifespan and healthspan extension in a mouse model with increased basal autophagy. To determine the effects of constitutively increased autophagy on mammalian health, we generated targeted mutant mice with a Phe121Ala mutation in beclin 1 (Becn1F121A/F121A) that...
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