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Article

Amelioration of progressive renal injury by genetic manipulation of <i>Klotho</i> gene

7 Feb 2007

Abstract excerpt

Klotho, an antiaging gene with restricted organ distribution, is mainly expressed in the kidney tubules; the mutant mice have shortened life span, arteriosclerosis, anemia, and osteoporesis, features common to patients with chronic renal failure. Conceivably, the reduction of the Klotho gene expression may contribute to the development of kidney failure; alternatively, its overexpression may lead to the...

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PMID: 17287345
DOI: 10.1073/pnas.0611079104

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Amelioration of progressive renal injury by genetic manipulation of <i>Klotho</i> genePMID 17287345Read ↗

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