Article
Genetic Polymorphisms Affecting Cardiac Biomarker Concentrations in Children with Cancer: an Analysis from the "European Paediatric Oncology Off-patents Medicines Consortium" (EPOC) Trial.
European journal of drug metabolism and pharmacokinetics - 1 Jun 2020
Hellmann Farina, Völler Swantje, Krischke Miriam, Jamieson David, André Nicolas, Bisogno Gianni, Boddy Alan, Hempel Georg
Abstract excerpt
BACKGROUND AND OBJECTIVES: Doxorubicin plays an essential role in the treatment of paediatric cancers. Defining genotypes with a higher risk for developing anthracycline-induced cardiotoxicity could help to reduce cardiotoxicity. METHODS: Data originated from a phase II study assessing the pharmacokinetics of doxorubicin in 100 children. Studied patients (0-17 years) were treated for solid tumours or leukaemia....
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