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Article

N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin.

G3 (Bethesda, Md.) - 28 Mar 2018

Ohkuni Kentaro, Levy-Myers Reuben, Warren Jack, Au Wei-Chun, Takahashi Yoshimitsu, Baker Richard E, Basrai Munira A

Abstract excerpt

Stringent regulation of cellular levels of evolutionarily conserved centromeric histone H3 variant (CENP-A in humans, CID in flies, Cse4 in yeast) prevents its mislocalization to non-centromeric chromatin. Overexpression and mislocalization of CENP-A has been observed in cancers and leads to aneuploidy in yeast, flies, and human cells. Ubiquitin-mediated proteolysis of Cse4 by E3 ligases such as Psh1 and...

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PMID: 29432128
DOI: 10.1534/g3.117.300419
PMCID: PMC5873912

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N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin.PMID 29432128Read ↗

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