Article
Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.
Nature communications - 24 Jan 2020
Zhu Ke, Lai Yumei, Cao Huiling, Bai Xiaochun, Liu Chuanju, Yan Qinnan, Ma Liting, Chen Di, Kanaporis Giedrius, Wang Junqi, Li Luyuan, Cheng Tao, Wang Yong, Wu Chuanyue, Xiao Guozhi
Abstract excerpt
β-Cell dysfunction and reduction in β-cell mass are hallmark events of diabetes mellitus. Here we show that β-cells express abundant Kindlin-2 and deleting its expression causes severe diabetes-like phenotypes without markedly causing peripheral insulin resistance. Kindlin-2, through its C-terminal region, binds to and stabilizes MafA, which activates insulin expression. Kindlin-2 loss impairs insulin secretion...
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