Article
Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.
Diabetes - 1 Jul 2018
Aslamy Arianne, Oh Eunjin, Olson Erika M, Zhang Jing, Ahn Miwon, Moin Abu Saleh Md, Tunduguru Ragadeepthi, Salunkhe Vishal A, Veluthakal Rajakrishnan, Thurmond Debbie C
Abstract excerpt
Loss of functional β-cell mass is an early feature of type 1 diabetes. To release insulin, β-cells require soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, as well as SNARE complex regulatory proteins like double C2 domain-containing protein β (Doc2b). We hypothesized that Doc2b deficiency or overabundance may confer susceptibility or protection, respectively, to the...
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