Article
Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure.
Circulation. Heart failure - 1 Aug 2016
Zhang Zhiyuan, Mu Yongxin, Veevers Jennifer, Peter Angela K, Manso Ana Maria, Bradford William H, Dalton Nancy D, Peterson Kirk L, Knowlton Kirk U, Ross Robert S, Zhou Xinmin, Chen Ju
Abstract excerpt
BACKGROUND: The striated muscle costamere, a multiprotein complex at the boundary between the sarcomere and the sarcolemma, plays an integral role in maintaining striated muscle structure and function. Multiple costamere-associated proteins, such as integrins and integrin-interacting proteins, have been identified and shown to play an increasingly important role in the pathogenesis of human cardiomyopathy....
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