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Article

Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Apr 2020

Davidson Matthew D, Khetani Salman R

Abstract excerpt

Primary human hepatocyte (PHH) cultures have become indispensable to mitigate the risk of adverse drug reactions in human patients. In contrast to dedifferentiating monocultures, coculture with nonparenchymal cells maintains PHH functions for 2-4 weeks. However, because the functional lifespan of PHHs in vivo is 200-400 days, it is desirable to further prolong PHH functions in vitro toward modeling chronic drug...

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Identifiers

PMID: 31977024
DOI: 10.1093/toxsci/kfaa003
PMCID: PMC7098377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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