Article

Induction of differentiation and metabolic reprogramming in human hepatoma cells by adult human serum

2017-08-25

Abstract excerpt

Tissue culture medium routinely contains fetal bovine serum (FBS). Here we show that culturing human hepatoma cells in their native, adult serum (human serum, HS) results in the restoration of key morphological and metabolic features of normal liver cells. When moved to HS, these cells show differential transcription of 22-32% of the genes, stop proliferating, and assume a hepatocyte-like morphology. Metabolic ana...

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Literature Corpus work: 17f09f31-3ade-5938-9ac4-b0e95ff22aa0
DOI: 10.1101/180968

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