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ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells

21 Dec 2011

Abstract excerpt

The interferon-stimulated gene 15 (ISG15) pathway is highly elevated in breast cancer; however, very little is known about how the ISG15 pathway contributes to breast tumorigenesis. In the current study, using the gene disruption approach, we demonstrate that both ISG15 and UbcH8 (ISG15-specific conjugating enzyme) disrupt F-actin architecture and formation of focal adhesions in ZR-75-1 breast cancer cells. In...

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Identifiers

PMID: 22185919
DOI: 10.1258/ebm.2011.011236

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