Article
Cohort Differences in the Associations of Selected Candidate Genes With Risk of All-Cause Mortality at Advanced Ages.
American journal of epidemiology - 1 Jul 2020
Tan Qihua, Jacobsen Rune, Nygaard Marianne, Soerensen Mette, Mengel-From Jonas, Christiansen Lene, Christensen Kaare
Abstract excerpt
Considerable efforts have been made to identify the genetic basis of human longevity, with only limited progress. One important drawback of current genetic studies is the limited knowledge of gene-environment interaction. Using 2 cohorts of long-lived individuals born in 1905 and 1915 in Denmark, we performed survival analysis to estimate risk of mortality for major candidate genes of aging and longevity and...
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