Article
Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility.
Clinical and experimental rheumatology - 1 Jan 2000
De Groof Aurélie, Ducreux Julie, Vidal-Bralo Laura, Tyteca Donatienne, Galant Christine, Marot Liliane, Coulie Pierre G, Van den Eynde Benoît J, Rodriguez-Martinez Lorena, Santos Maria Jose, Suarez Ana, Carreira Patricia, Marchini Maurizio, Gonzàlez Antonio, Houssiau Frédéric A, Lauwerys Bernard R
Abstract excerpt
OBJECTIVES: TLR3 mediates skin solar injury by binding nuclear material released from apoptotic keratinocytes, resulting in the production of pro-inflammatory cytokines. Because the TLR3 gene is located in 4q35, a known systemic lupus erythematosus (SLE) susceptibility locus, we wondered whether TLR3 single nucleotide polymorphisms (SNPs) were associated with inflammatory mechanisms relevant to the development of...
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