Article
The ID genotype of MDM2 40 bp insertion/deletion polymorphism was associated with lower risk of SLE.
Postgraduate medical journal - 1 Dec 2017
Salimi Saeedeh, Rezaei Mahnaz, Mohammadpour-Gharehbagh Abbas, Sajadian Mojtaba, Sandoughi Mahnaz
Abstract excerpt
BACKGROUND: In patients with systemic lupus erythematosus (SLE), loss of immunological tolerance to self-nuclear antigens and abnormal activation of self-reactive T and B cells lead to self-antibodies and immune complex production. The autoreactive lymphocytes are removed by the apoptotic process in healthy individuals; however, apoptosis disruption could cause accumulation of apoptotic bodies and nuclear debris....
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