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Article

Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus.

Arthritis and rheumatism - 1 Jan 2009

Bertsias George K, Nakou Magda, Choulaki Christianna, Raptopoulou Amalia, Papadimitraki Eva, Goulielmos George, Kritikos Herakles, Sidiropoulos Prodromos, Tzardi Maria, Kardassis Dimitris, Mamalaki Clio, Boumpas Dimitrios T

Abstract excerpt

OBJECTIVE: A putative regulatory intronic polymorphism (PD1.3) in the programmed death 1 (PD-1) gene, a negative regulator of T cells involved in peripheral tolerance, is associated with increased risk for systemic lupus erythematosus (SLE). We undertook this study to determine the expression and function of PD-1 in SLE patients. METHODS: We genotyped 289 SLE patients and 256 matched healthy controls for PD1.3 by...

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Identifiers

PMID: 19116915
DOI: 10.1002/art.24227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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