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Article

A potential association between IL‐3 and type I and III interferons in systemic lupus erythematosus

1 Jan 2019

Abstract excerpt

Abstract Objectives Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are major contributors to systemic lupus erythematosus (SLE) pathogenesis. IL‐3 promotes pDC survival, but its role in SLE is not well characterised. This study investigated serum IL‐3 and IFN levels, and a whole blood ‘IL‐3 gene signature’, in human SLE. Methods Serum cytokine levels...

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PMID: 31890206
DOI: 10.1002/cti2.1097

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