Article
Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients.
Annals of the rheumatic diseases - 1 Apr 2013
Jensen Mark A, Patterson Karen C, Kumar Akaash A, Kumabe Marissa, Franek Beverly S, Niewold Timothy B
Abstract excerpt
OBJECTIVE: Hyperactivity of the type I interferon (IFN) pathway is involved in the pathogenesis of systemic lupus erythematosus (SLE). Immunoglobulin like transcript (ILT3) is an immunohibitory transmembrane molecule which is induced by type I IFNs. ILT3 is expressed by plasmacytoid dendritic cells (PDCs), monocytoid dendritic cells (MDCs), and monocytes/macrophages. Given the pathogenic role of IFN in SLE, we...
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