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Article

Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus.

Scientific reports - 12 Apr 2021

Perez-Bercoff Danielle, Laude Hélène, Lemaire Morgane, Hunewald Oliver, Thiers Valérie, Vignuzzi Marco, Blanc Hervé, Poli Aurélie, Amoura Zahir, Caval Vincent, Suspène Rodolphe, Hafezi François, Mathian Alexis, Vartanian Jean-Pierre, Wain-Hobson Simon

Abstract excerpt

APOBEC3 (A3) enzymes are best known for their role as antiviral restriction factors and as mutagens in cancer. Although four of them, A3A, A3B, A3F and A3G, are induced by type-1-interferon (IFN-I), their role in inflammatory conditions is unknown. We thus investigated the expression of A3, and particularly A3A and A3B because of their ability to edit cellular DNA, in Systemic Lupus Erythematosus (SLE), a chronic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33846459
DOI: 10.1038/s41598-021-87024-1
PMCID: PMC8041901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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