Article

Helicobacter pylori cancer associated CagA protein drives intestinal metaplastic transition in human gastric organoids

2023-11-22

Abstract excerpt

Gastric intestinal metaplasia (GIM) constitutes a pre-neoplastic stage in the development of stomach cancer. While strong evidence points to a role of infection with CagA positive Helicobacter pylori in the development of GIM, currently available experimental models have not provided mechanistic clues on this association. Here, we ectopically expressed the H. pylori CagA protein in human gastric organoids derive...

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Literature Corpus work: 0e9c22fd-c134-5fe3-91f5-34e973965d24
DOI: 10.1101/2023.11.22.567682

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